Light-induced effects in sulfonated aluminum phthalocyanines—potential photosensitizers in the photodynamic therapy Spectroscopic and kinetic study
نویسندگان
چکیده
Light-induced effects in sulfonated aluminum phthalocyanines—potential photosensitizers in the photodynamic therapy Spectroscopic and kinetic study Krystyna Palewska a,∗, Marta Sujka a,1, Barbara Urasińska-Wójcik a,2, Juliusz Sworakowski a, Józef Lipiński a, Stanislav Nešpůrek b, Jan Rakušan c, Marie Karásková c a Institute of Physical and Theoretical Chemistry, Wrocław University of Technology, Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland b Institute of Macromolecular Chemistry AS CR, v. v. i., Heyrovský Sq. 2, 162 06 Prague 6, Czech Republic c Research Institute of Organic Synthesis, 532 18 Pardubice-Rybitvı́, Czech Republic
منابع مشابه
Photodynamic therapy (PDT)
Photodynamic therapy (PDT) is a comparatively novel therapeutic method involving a safe light source and a light-sensitive substance, termed as photosensitizers (PSs), such as methylene blue (MB), toluidine blue (TBO), sulfonated aluminum phthalocyanine, chlorine derivatives, nontoxic indocyanine green (ICG), and curcumin (CUR). (1) The combination of a nontoxic PS with low-intensity visible li...
متن کاملAmphiphilic zinc phthalocyanine photosensitizers: synthesis, photophysicochemical properties and in vitro studies for photodynamic therapy.
Peripherally and non-peripherally tetra-substituted zinc(ii) phthalocyanines bearing 2-(2-{2-[3-(dimethylamino)phenoxy]ethoxy}ethoxy)ethoxy and 2-(2-{2-[3-(diethylamino)phenoxy]ethoxy}ethoxy)ethoxy groups (, , and ) were synthesized by cyclotetramerization of the corresponding phthalonitriles (, , and ). Their quaternized ionic derivatives (, , and ) were also synthesized by the reaction of the...
متن کاملبررسی اثر فتودینامیکی کمپلکس تتراپیریدینو پورفیرازین روی (II)، بر ردهی سلولی HeLa
Background and Objective: Photodynamic therapy is a treatment that uses photosensitizer and intense visible light. When photosensitizers get exposed to a specific light wavelength (preferentially in the red region), they produce reactive oxygen species that are toxic to cells. Recently, attention has been focused on porphyrins and their analogs as photosensitizers. Zn (II) tetrapyridinoporphyra...
متن کاملQuantum dot-aluminum phthalocyanine conjugates perform photodynamic reactions to kill cancer cells via fluorescence resonance energy transfer
Sulfonated aluminum phthalocyanines (AlPcSs), commonly used photosensitizers for photodynamic therapy of cancers (PDT), were conjugated with amine-dihydrolipoic acid-coated quantum dots (QDs) by electrostatic binding, achieving 70 AlPcSs per QD. The AlPcS-QD conjugates can utilize the intense light absorptions of conjugated QDs to indirectly excite AlPcSs producing singlet oxygen via fluorescen...
متن کاملUltrastructural effects of two phthalocyanines in CHO-K1 and HeLa cells after laser irradiation.
The effects of Photodynamic Therapy using 2nd generation photosensitizers have been widely investigated aiming clinical application treatment of solid neoplasms. In this work, ultrastructure changes caused by the action of two 2nd generation photosensitizers and laser irradiation on CHO-K1 and HeLa (neoplastic) cells were analyzed by transmission electron microscopy. Aluminum phthalocyanine chl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008